The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives
| Autor: | Yifan Li, Wei Hu, Mingxing Li, Zhangang Xiao, Xu Wu, Lan Lu, Fukuan Du, Zhigui Wu, Chi Hin Cho, Yueshui Zhao, Qianxiu Li, Jing Shen, Yu Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Helicobacter pylori infection
Drug resistance Review Applied Microbiology and Biotechnology Metastasis Helicobacter Infections Stomach Neoplasms medicine Biomarkers Tumor Tumor Microenvironment Humans Molecular Biology Ecology Evolution Behavior and Systematics Tumor microenvironment drug resistance biology Helicobacter pylori long non-coding RNA business.industry gastric cancer Cancer Cell Biology medicine.disease biology.organism_classification Long non-coding RNA Drug Resistance Neoplasm Cancer research RNA Long Noncoding Signal transduction business Developmental Biology Signal Transduction |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Gastric cancer (GC) is one of the major public health concerns. Long non-coding RNAs (lncRNAs) have been increasingly demonstrated to possess a strong correlation with GC and play a critical role in GC occurrence, progression, metastasis and drug resistance. Many studies have shed light on the understanding of the underlying mechanisms of lncRNAs in GC. In this review, we summarized the updated research about lncRNAs in GC, focusing on their roles in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets. The research gaps and future directions were also discussed. |
| Databáze: | OpenAIRE |
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