Cerasomal Lovastatin Nanohybrids for Efficient Inhibition of Triple-Negative Breast Cancer Stem Cells To Improve Therapeutic Efficacy
| Autor: | Xiyun Deng, Huimei Yi, Guangchun He, Siyuan Tan, Zhong Cao, Guangyang Zou, Li Lin, Hui Yao, Lu Lu, Shichao Yan, Zhifei Dai, Wanxin Ouyang, Di Wu, Chao Chen, Xiaojun Tao, Liujiang Song |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition Materials science Angiogenesis Apoptosis Triple Negative Breast Neoplasms Mammary gland formation 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer stem cell Cell Line Tumor medicine Humans General Materials Science Lovastatin Epithelial–mesenchymal transition Triple-negative breast cancer Cell Proliferation medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research Female Stem cell medicine.drug |
| Zdroj: | ACS Applied Materials & Interfaces. 10:7022-7030 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.8b01633 |
| Popis: | Triple-negative breast cancer (TNBC) is a subtype of breast cancer with a higher risk in younger women and a poorer prognosis and without targeted therapies available currently. Cancer stem cells (CSCs) are increasingly recognized as the main cause of treatment failure and tumor recurrence. The present paper reports the encapsulation of lovastatin (LV) into cerasomes. Compared with free LV, cerasome-encapsulated LV (C-LV) nanohybrids showed cytotoxicity to MDA-MB-231 CSCs in a dose- and time-dependent manner. Furthermore, intravenous injection of C-LV nanohybrids resulted in a significant tumor size reduction in a dose-dependent manner in xenograft tumors derived from subcutaneous inoculation of MDA-MB-231 cells. Furthermore, histopathological and/or immunohistochemical analysis revealed that C-LV nanohybrids significantly induced mammary gland formation and apoptosis and inhibited angiogenesis, the CSC phenotype, and the epithelial-to-mesenchymal transition in xenograft tumors. Most importantly, C-LV nanohybrids were found to be more effective than free LV in inhibiting the growth of breast cancer xenografts and the stemness properties in vivo. To the best of our knowledge, ours is the first demonstration of nanohybrids for efficient inhibition of CSCs derived from TNBC, offering a new option for the TNBC treatment. |
| Databáze: | OpenAIRE |
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