Cerebral amyloid-β accumulation and deposition following traumatic brain injury--A narrative review and meta-analysis of animal studies
| Autor: | Belinda M. Brown, Giuseppe Verdile, Michael Weinborn, Sabine Bird, Veer Bular Gupta, Romola S. Bucks, Leigh Patterson, Kevin Taddei, Malcolm Carruthers, Neville W. Knuckey, Nat Lenzo, Ralph N. Martins, Stephanie R. Rainey-Smith, Thomas A. Sutton, Hamid R. Sohrabi |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Amyloid β Traumatic brain injury Cognitive Neuroscience Disease Bioinformatics Pathogenesis 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Brain Injuries Traumatic medicine Dementia Animals Humans Amyloid beta-Peptides business.industry Brain medicine.disease nervous system diseases 030104 developmental biology Neuropsychology and Physiological Psychology Meta-analysis Narrative review Animal studies business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and biobehavioral reviews. 64 |
| ISSN: | 1873-7528 |
| Popis: | Traumatic brain injury (TBI) increases the risk of neurodegenerative disorders many years post-injury. However, molecular mechanisms underlying the relationship between TBI and neurodegenerative diseases, such as Alzheimer's disease (AD), remain to be elucidated. Nevertheless, previous studies have demonstrated a link between TBI and increased amyloid-β (Aβ), a protein involved in AD pathogenesis. Here, we review animal studies that measured Aβ levels following TBI. In addition, from a pool of initially identified 1209 published papers, we examined data from 19 eligible animal model studies using a meta-analytic approach. We found an acute increase in cerebral Aβ levels ranging from 24h to one month following TBI (overall log OR=2.97 ± 0.40, p |
| Databáze: | OpenAIRE |
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