| Autor: |
Brian Reed, Michael Miller, Mayako Michino, Eduardo R. Butelman, Ariel Ben-Ezra, Philip Pikus, Michelle Morochnik, Yuli Kim, Amy Ripka, Joseph Vacca, Mary Jeanne Kreek |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS Chemical Neuroscience. 13:1849-1856 |
| ISSN: |
1948-7193 |
| DOI: |
10.1021/acschemneuro.2c00258 |
| Popis: |
The kappa agonist structure-activity relationship around the novel, pyrrolidinyl substituted pyranopiperazine scaffold was developed. More specifically, the dichloroPhenylAcetamide-Pyrrolidinyl-PyranoPiperazine (PAPPP) core A was the focus of our work. The modulation of kappa receptor potency/G-protein activation and arrestin recruitment with respect to changes of the piperazine R group in A was demonstrated. Reduced β |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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