Bioactive constituents of the stem bark of Mitrephora glabra

Autor:	Norman R. Farnsworth, Tyler N. Graf, Sharnelle S. Phifer, Djaja D. Soejarto, Mansukh C. Wani, Fransisca M. Setyowati, Yuka Nakanishi, Nicholas H. Oberlies, A. Douglas Kinghorn, Chen Li, Soedarsono Riswan, Achmad M. Saribi, Joseph O. Falkinham, Dongho Lee, David J. Kroll
Rok vydání:	2009
Předmět:	Aporphines Pharmaceutical Science Annonaceae Microbial Sensitivity Tests Saccharomyces cerevisiae Pharmacognosy Article Analytical Chemistry Mycobacterium chemistry.chemical_compound Mitrephora Anti-Infective Agents Drug Discovery Botany Plant Bark Humans Aporphine Nuclear Magnetic Resonance Biomolecular Pharmacology Plants Medicinal Traditional medicine biology Molecular Structure Organic Chemistry Liriodenine Polyynes biology.organism_classification Antineoplastic Agents Phytogenic Micrococcus luteus Complementary and alternative medicine chemistry Indonesia visual_art visual_art.visual_art_medium Molecular Medicine Bark Female Aspergillus niger Diterpene Diterpenes Drug Screening Assays Antitumor
Zdroj:	Journal of natural products. 72(11)
ISSN:	1520-6025
Popis:	Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1−3), five polyacetylenic acids/esters (4−8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1−3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23de7ed25aaf660ef0126d6641e660c https://pubmed.ncbi.nlm.nih.gov/19874044 Zobrazit plný text záznamu