Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure
| Autor: | Laura Font, Raúl Pastor, Ileana Morales, Olga Rodríguez-Borillo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Sucrose medicine.drug_class saccharin media_common.quotation_subject Narcotic Antagonists Binge drinking Alcohol Self Administration Pharmacology Naltrexone Article Binge Drinking 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Saccharin Opioid receptor mental disorders Medicine Animals rat Neuropharmacology media_common Ethanol business.industry Addiction Antagonist sucrose 030227 psychiatry Behavior Addictive Mice Inbred C57BL Psychiatry and Mental health chemistry binge-like drinking Models Animal addiction ethanol business naltrexone 030217 neurology & neurosurgery Binge-Eating Disorder medicine.drug |
| Zdroj: | Behav Pharmacol Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1473-5849 |
| Popis: | Chronic alcohol (ethyl alcohol, EtOH) binging has been associated with long-term neural adaptations that lead to the development of addiction. Many of the neurobiological features of EtOH abuse are shared with other forms of binging, like pathological feeding. The drinking-in-the-dark (DID) paradigm has been used extensively to study the neurobiology of EtOH binge-like drinking due to its ability to promote high intakes relevant to human behavior. DID can also generate high consumption of other tastants, but this procedure has not been fully adapted to study forms of binging behavior that are not alcohol-driven. In the present study, we used a modified version of DID that uses multiple bottle availability to promote even higher levels of EtOH drinking in male C57BL/6J mice and allows a thorough investigation of tastant preferences. We assessed whether administration of systemic naltrexone could reduce binging on EtOH, sucrose, and saccharin separately as well as in combination. Our multiple bottle DID procedure resulted in heightened levels of consumption compared with previously reported data using this task. We found that administration of the opioid receptor antagonist naltrexone reduced intakes of preferred, highly concentrated EtOH, sucrose, and saccharin. We also report that naltrexone was able to reduce overall intakes when animals were allowed to self-administer EtOH, sucrose, or saccharin in combination. Our modified DID procedure provides a novel approach to study binging behavior that extends beyond EtOH to other tastants (i.e. sucrose and artificial sweeteners), and has implications for the study of the neuropharmacology of binge drinking. |
| Databáze: | OpenAIRE |
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