Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing
| Autor: | Antonios G. Kanaras, Tom Brown, Amelie Heuer-Jungemann, Pascal K. Harimech |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Cell Survival Nanoparticle Metal Nanoparticles Nucleic Acid Hybridization Nanotechnology Biosensing Techniques DNA Small molecule DNA metabolism Nucleic acid thermodynamics chemistry.chemical_compound chemistry Microscopy Fluorescence Colloidal gold Neoplasms diagnosis Neoplasms Nucleic acid Humans General Materials Science Gold Fluorescent Dyes |
| Zdroj: | Nanoscale. 5(20) |
| ISSN: | 2040-3372 |
| Popis: | In the past decade gold nanoparticle–nucleic acid conjugates became progressively important for biomedical applications. Fluorophores attached to nucleic acid–gold nanoparticle conjugates have opened up a new era of biological sensing. The most promising advancement in this field was the invention of the so-called ‘nano-flare’ systems. These systems are capable of detecting specific endocellular targets such as mRNAs, microRNAs or small molecules in real time. In this minireview, we discuss the current progress in the field of DNA–nanoparticles as sensors, their properties, stability, cellular uptake and cytotoxicity. |
| Databáze: | OpenAIRE |
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