The difficulty of height prediction in Weaver syndrome
| Autor: | M Jansen, J F van Gils, P G Voorhoeve |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pediatrics
medicine.medical_specialty Growth data Pathology and Forensic Medicine Craniofacial Abnormalities Predictive Value of Tests medicine High doses Humans Abnormalities Multiple Child Growth Disorders Genetics (clinical) Weaver syndrome business.industry Final height Bone age General Medicine Prognosis medicine.disease Normal limit Body Height Accelerated Growth Predictive value of tests Pediatrics Perinatology and Child Health cardiovascular system Female Anatomy business Hand Deformities Congenital circulatory and respiratory physiology |
| Zdroj: | Clinical Dysmorphology. 11:49-52 |
| ISSN: | 0962-8827 |
| DOI: | 10.1097/00019605-200201000-00010 |
| Popis: | Accelerated growth and advanced bone age are consistent findings in Weaver-Smith syndrome (WSS). According to the rather scant reports in the literature, persons afflicted with WSS appear to achieve supranormal heights despite a significant bone age advancement in their growth period. The literature does not state clearly whether there is a discrepancy between bone age advancement and the time of onset of puberty in WSS. We report a girl with Weaver syndrome whose final height predictions were within normal limits according to the standard prediction models, who had to be eventually treated with high doses of estrogen in order to keep her final height within reasonable limits. We conclude that the pattern of growth and maturation in children with WSS may form an exception to the general rule that tall children with an advanced bone age mature early and thus attain a normal final height. A careful evaluation of growth data of other children with WSS is necessary to clarify this issue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|