Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens
| Autor: | N O Calixto, Kátia Costa de Carvalho Sabino, Marcia Cristina Paes, Patrícia A. Reis, Sergio Ranto Dalmau, C.S. Lopes, A R Todeschini, Carlos Roberto Machado Gayer, Maria Cristina da Costa e Silva, Marsen Garcia Pinto Coelho, Caroline Passaes |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Administration Topical Pharmaceutical Science High-performance liquid chromatography Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Mice Geranylgeraniol Indometacin medicine Animals Edema Chromatography High Pressure Liquid Pharmacology biology Traditional medicine Chemistry Plant Extracts Extraction (chemistry) Fabaceae Farnesol biology.organism_classification Croton Carrageenan Biochemistry Seeds Diterpene Injections Intraperitoneal medicine.drug Phytotherapy |
| Zdroj: | The Journal of pharmacy and pharmacology. 56(1) |
| ISSN: | 0022-3573 |
| Popis: | We previously demonstrated that alcoholic extracts from Pterodon pubescens Benth. (Sucupira branca, Leguminosae) seeds exhibit anti-arthritic activity. In the present work we show that the oleaginous extract obtained from P. pubescens seeds (OEP) exhibits acute or topic anti-edematogenic activity when tested in carrageenan-induced paw edema or in croton oil-induced ear edema assays, respectively. Four fractions were obtained from OEP by sequential liquid–liquid extraction. The anti-edematogenic properties were predominant in the hexanic fraction, which was further fractionated by HPLC, yielding three sub-fractions (PF1.1, PF1.2 and PF1.3). PF1.1 and PF1.3 showed potent acute and topic anti-edematogenic activity. The PF1.2 sub-fraction, although not active in the carrageenan assay, exhibited a potent anti-edematogenic activity in the croton oil-induced ear edema. This sub-fraction shows a maximum efficacy similar to indometacin in a lower dose. The PF1.1 sub-fraction presented a complex mixture containing furane diterpene derivatives of vouacapan. PF1.2 consists of a single substance, geranylgeraniol, as determined by GC/MS and NMR, while PF1.3 contains farnesol. |
| Databáze: | OpenAIRE |
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