Stepwise Expression of CDKN2A and RB1 Proteins in Esophageal Mucosa From Patients at High Risk for Squamous Cell Carcinoma
| Autor: | Luise Meurer, Sara Sgarioni Vanazzi, Renato Borges Fagundes, Leandro B. Müller, Luis Carlos Moreira Antunes, Antonio de Barros Lopes |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology medicine.medical_specialty Histology Esophageal Neoplasms Retinoblastoma Protein Gastroenterology Pathology and Forensic Medicine Malignant transformation Risk Factors Internal medicine Carcinoma Humans Medicine Esophagus Cyclin-Dependent Kinase Inhibitor p16 Mucous Membrane business.industry Carcinoma in situ Cancer medicine.disease Gene Expression Regulation Neoplastic Medical Laboratory Technology Cell Transformation Neoplastic medicine.anatomical_structure Dysplasia Carcinoma Squamous Cell Female business Esophagitis |
| Zdroj: | Applied Immunohistochemistry & Molecular Morphology. 22:669-673 |
| ISSN: | 1541-2016 |
| Popis: | Squamous cell carcinoma of the esophagus is a lethal cancer and carries a poor prognosis because of late diagnosis. Identification of molecular markers may aid early diagnosis. We assessed the expression of CDKN2A/RB1 in the esophageal mucosa and its association with the histology. Esophageal biopsies were collected from 38 patients with no esophageal lesion (group 1), from iodine-negative areas of 108 alcoholics/smokers (group 2), and from tumor and nontumor areas in 41 patients with squamous cell carcinoma (group 3). The histologic diagnosis was compared with immunoexpression of CDKN2A/RB1. In group 1, histology showed normal mucosa/mild esophagitis and no expression of CDKN2A/RB1. In groups 2 and 3, the diagnosis was: normal mucosa (38.4%), esophagitis (44.4%), dysplasia and carcinoma in situ (2.8%), and carcinoma (14.3%). The immunoexpression of CDKN2A/RB1 increased in a stepwise manner from the normal mucosa, to esophagitis, dysplasia/carcinoma in situ, and carcinoma (P |
| Databáze: | OpenAIRE |
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