Nucleosides with Transposed Base or 4′-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides
| Autor: | Piet Herdewijn, Marleen Renders, Serge Van Calenbergh, Elisabetta Groaz, Kiran S. Toti |
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| Rok vydání: | 2015 |
| Předmět: |
ISOMERIC DIDEOXYNUCLEOSIDES
EXOCYCLIC METHYLENE Stereochemistry government.form_of_government Oligonucleotides Antineoplastic Agents Antiviral Agents IN-VITRO SELECTION Nucleobase chemistry.chemical_compound Animals Humans Nucleotide Hydroxymethyl BIOLOGICAL EVALUATION Nucleic acid structure chemistry.chemical_classification Antisense therapy NUCLEIC-ACID STRUCTURE Molecular Structure biology ANTI-HIV AGENTS Oligonucleotide Nucleosides General Chemistry POTENTIAL ANTIVIRAL AGENTS 3. Good health Integrase Chemistry STEREOSELECTIVE-SYNTHESIS chemistry SUBSTITUTED APIO DIDEOXYNUCLEOSIDES biology.protein government L-RELATED ISODEOXYNUCLEOSIDES Nucleoside |
| Zdroj: | CHEMICAL REVIEWS |
| ISSN: | 1520-6890 0009-2665 |
| DOI: | 10.1021/acs.chemrev.5b00545 |
| Popis: | This review focuses on 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nucleotides, and nucleoside phosphonates, their stereoisomers, and their close analogues. The biological activities of all known 4'-hydroxymethyl- or nucleobase-transposed nucleosides, nucleotides, and nucleoside phosphonates as potential antiviral or anticancer agents are compiled. The routes that have been taken for the chemical synthesis of such nucleoside derivatives are described, with special attention to the innovative strategies. The enzymatic synthesis, base-pairing properties, structure, and stability of oligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides are discussed. The use of oligonucleotides containing nucleobase- or 4'-hydroxymethyl-transposed nucleotides as small oligonucleotide (e.g., human immunodeficiency virus integrase) inhibitors, in applications such as antisense therapy, silencing RNA (siRNA), or aptamer selections, is detailed. ispartof: Chemical Reviews vol:115 issue:24 pages:13484-525 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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