Serum Cardiac Markers in Patients with Acute Myocardial Infarction: Oxidative Stress, C-Reactive Protein and N-Terminal Probrain Natriuretic Peptide
| Autor: | Aymelek Gönenç, Seçil Kasap, Derya Erten Şener, İsmet Hisar |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Thiobarbituric acid Clinical Biochemistry acute myocardial infarction Medicine (miscellaneous) medicine.disease_cause C-reactive protein chemistry.chemical_compound Diabetes mellitus Internal medicine Hyperlipidemia Natriuretic peptide oxidative stress Medicine cardiovascular diseases Myocardial infarction Nutrition and Dietetics biology business.industry medicine.disease Malondialdehyde N-terminal probrain natriuretic peptide Endocrinology chemistry biology.protein Original Article business Oxidative stress |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 0912-0009 |
| Popis: | The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (NIDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p < 0.01). Patients were divided into six groups based on the presence of disease history before AMI. In patients with non-disease before AMI. MDA, CRP and NT-proBNP levels were lowest among the patient groups. MDA levels in patients with hyperlipidemia/diabetes/renal disease were higher than the other groups. TAC levels in patients with hypertension were lower than as compared to healthy controls (p < 0.05). CRP levels in hypertension + hyperlipidemia patients and NT-proBNP levels in cardiovascular + hypertension patients were found high as compared to other patient groups. It is concluded that serum levels of MDA, CRP and NT-proBNP were significantly increased in patients with AMI and these markers were strongly predictive in AMI. |
| Databáze: | OpenAIRE |
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