A Novel Hybrid Membrane VAD as First Step Toward Hemocompatible Blood Propulsion
| Autor: | Tanja Schmidt, Mathias Rebholz, Giovanni Pellegrini, Bente Thamsen, Edoardo Mazza, Costanza Giampietro, Mirko Meboldt, Aldo Ferrari, Peter Zilla, Sarah Kitz, Vita Marina, Simon H. Sündermann, Evgenij V. Potapov, Björn Bachmann, Raoul Hopf, Georgios Stefopoulos, Christoph Starck, Gerald Kress, Paolo Ermanni, Deon Bezuidenhhout, Dimos Poulikakos, L. Bernardi, Volkmar Falk, Marianne Schmid Daners, Christian Loosli |
|---|---|
| Přispěvatelé: | University of Zurich, Ferrari, Aldo, Falk, Volkmar, Mazza, Edoardo |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Wall deformation
Computer science medicine.medical_treatment Biomedical Engineering 10184 Institute of Veterinary Pathology 2204 Biomedical Engineering VAD Endothelialization Wall shear stress Hyperelastic membrane Context (language use) 02 engineering and technology 030204 cardiovascular system & hematology Propulsion 03 medical and health sciences 0302 clinical medicine Coronary Circulation medicine Animals Cells Cultured Heart transplantation Sheep Endothelial Cells Membranes Artificial Equipment Design Stroke volume 021001 nanoscience & nanotechnology medicine.disease Proof of concept Ventricular assist device Heart failure Hydrodynamics 570 Life sciences biology Original Article Heart-Assist Devices 0210 nano-technology Biomedical engineering Destination therapy |
| Zdroj: | Annals of Biomedical Engineering, 49 (2) Annals of Biomedical Engineering |
| ISSN: | 1573-9686 0191-5649 0090-6964 |
| Popis: | Heart failure is a raising cause of mortality. Heart transplantation and ventricular assist device (VAD) support represent the only available lifelines for end stage disease. In the context of donor organ shortage, the future role of VAD as destination therapy is emerging. Yet, major drawbacks are connected to the long-term implantation of current devices. Poor VAD hemocompatibility exposes the patient to life-threatening events, including haemorrhagic syndromes and thrombosis. Here, we introduce a new concept of artificial support, the Hybrid Membrane VAD, as a first-of-its-kind pump prototype enabling physiological blood propulsion through the cyclic actuation of a hyperelastic membrane, enabling the protection from the thrombogenic interaction between blood and the implant materials. The centre of the luminal membrane surface displays a rationally-developed surface topography interfering with flow to support a living endothelium. The precast cell layer survives to a range of dynamically changing pump actuating conditions i.e., actuation frequency from 1 to 4 Hz, stroke volume from 12 to 30 mL, and support duration up to 313 min, which are tested both in vitro and in vivo, ensuring the full retention of tissue integrity and connectivity under challenging conditions. In summary, the presented results constitute a proof of principle for the Hybrid Membrane VAD concept and represent the basis for its future development towards clinical validation. Annals of Biomedical Engineering, 49 (2) ISSN:1573-9686 ISSN:0191-5649 ISSN:0090-6964 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink