Histologic changes resembling acute rejection in a liver transplant patient treated with terbinafine
| Autor: | Michael O. Lovell, Russell D. Havranek, Kermit V Speeg, Francis E. Sharkey |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Pathology Antifungal Agents Nausea Biopsy medicine.medical_treatment Naphthalenes Liver transplantation Gastroenterology Pathology and Forensic Medicine Diagnosis Differential Cholestasis Internal medicine medicine Humans Terbinafine business.industry Bile duct Immunosuppression Middle Aged Jaundice medicine.disease Liver Transplantation Transplantation medicine.anatomical_structure Liver Bile Ducts medicine.symptom business medicine.drug |
| Zdroj: | Human Pathology. 34:187-189 |
| ISSN: | 0046-8177 |
| DOI: | 10.1053/hupa.2003.16 |
| Popis: | We present a case of histologic changes resembling acute cellular rejection in a liver transplant patient treated with terbinafine. Approximately 5 years after orthotopic liver transplantation, a 51-year-old Hispanic man developed elevated liver enzyme levels. A biopsy sample was interpreted as acute cellular rejection, and the patient was treated with increased immunosuppression. Review of medications showed that the patient had been started on terbinafine approximately 4 weeks earlier for onychomycosis, and it was discontinued. A follow-up visit 2 weeks later revealed progressive jaundice, malaise, and nausea, and evaluation of a second liver biopsy sample revealed marked centrilobular cholestasis and severe bile duct damage, consistent with terbinafine hepatotoxicity. Although these histologic changes have been described in treated patients with both normal and abnormal livers, the potential for confusion with acute rejection in patients with hepatic transplantation has not previously been reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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