Early postpartum abnormal glucose metabolism subtype differs according to mid-trimester lipid profile in women with gestational diabetes mellitus
| Autor: | Xiaopei Cao, Ling Pei, Haipeng Xiao, Huangmeng Xiao, Shufan Yue, Yanbing Li, Zhuyu Li, Fenghua Lai, Zeting Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty RC620-627 endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Clinical nutrition Gestational diabetes mellitus chemistry.chemical_compound Endocrinology Pregnancy Postpartum Humans Insulin Medicine Nutritional diseases. Deficiency diseases Triglycerides Dyslipidemias Retrospective Studies Glucose metabolism Triglyceride medicine.diagnostic_test business.industry Obstetrics Research Biochemistry (medical) nutritional and metabolic diseases Cholesterol LDL Odds ratio Glucose Tolerance Test medicine.disease Lipids Lipid profile Gestational diabetes Diabetes Gestational Glucose chemistry Pregnancy Trimester Second Gestation Female Insulin Resistance Mid-trimester business Dyslipidemia Lipidology |
| Zdroj: | Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021) Lipids in Health and Disease |
| ISSN: | 1476-511X |
| DOI: | 10.1186/s12944-021-01519-4 |
| Popis: | Background It is unknown whether early postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) is related to their mid-trimester lipid profile. The aim of this study was to characterize the mid-trimester lipid profile of women who experienced GDM and developed into different pathophysiologic subtypes of early postpartum AGM. Methods A retrospective cohort study of 498 women with history of GDM was conducted. A 75-g oral glucose tolerance test (OGTT) and plasma lipid measurements were performed at 24–28 weeks of gestation and 6–12 weeks of postpartum. Insulin secretion and sensitivity were estimated using early postpartum OGTT-based indices. Results Women in the mid-trimester dyslipidemia group had higher postpartum 30-min and 2-h plasma glucose, higher postpartum 2-h plasma insulin, higher postpartum triglyceride (TG), higher postpartum low density lipoprotein cholesterol (LDL-c) concentrations, lower postpartum 30-min insulinogenic index (IGI30), lower postpartum insulin sensitivity index (ISI), and lower postpartum disposition index than those in the normal lipid group (all P P 30 and low ISI had higher mid-trimester total cholesterol and LDL-c concentrations, and AGM women with low ISI had higher mid-trimester TG concentrations than women with NGT or other subtypes of AGM (all P Conclusions GDM women with abnormal mid-trimester TG and LDL-c were predisposed to early postpartum AGM. Postpartum AGM women who experienced GDM had heterogeneous mid-trimester lipid profile when classified according to their pathophysiologic subtype. |
| Databáze: | OpenAIRE |
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