Investigation of cytokine gene polymorphisms in patients with psoriasis vulgaris
| Autor: | Odabas, H., Gumus, M., Ozcelik, M., Ercelep, O., Aliustaoglu, M., Ustaalioglu, B. B. Oven, Oyman, A., Isik, S., Isik, D., Surmeli, H., Aydin, D., Mert, A. G., Yuksel, S. |
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| Přispěvatelé: | ONSUN, Nahide |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
gene polymorphisms business.industry Dermatology lcsh:RL1-803 medicine.disease lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 030207 dermatology & venereal diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cinar C. K. Karahan G. E. Temurhan S. Pirmit S. ONSUN N. Oguz F. S. -Investigation of cytokine gene polymorphisms in patients with psoriasis vulgaris- TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY cilt.50 ss.34-38 2016 Psoriasis Immunology cytokine lcsh:Dermatology Medicine Cytokine genes In patient business Psoriasis vulgaris |
| Zdroj: | Türkderm, Vol 50, Iss 1, Pp 34-38 (2016) |
| Popis: | Psoriasis is associated with cutaneous and systemic overexpression of several proinflammatory cytokines. The aim of this study was to investigate the relationship between susceptibility to psoriasis and polymorphisms of tumor necrosis factor alpha (TNF-alpha), interferon gamma (INF-gamma), interleukin (IL-10), IL-6 and transforming growth factor beta (TGF-beta). Eighty-nine patients with psoriasis and 201 healthy controls were enrolled into the study. The patient group was divided into 2 subgroups as early-onset (group 1) and late-onset (group 2). The cytokine gene polymorphisms in each group were determined by polymerase chain reaction-single specific primer. When the whole and only group 1 patients were compared with the controls, TGF-beta TT/GC genotype was significantly high in the whole and group 1 patients. When we compared the group 1 and group 2, the frequency of IFN-gamma AA genotype was found to be significantly high in group 1 which lost significance after Bonferroni correction. Patients with moderate symptoms had a significantly high frequency of IL-10 GCC/GCC genotype that did not remain significant after correction. These data from our small group of patients demonstrated that the only significant difference between the whole patient group and the controls was for TGF-beta TT/GC genotype with a higher frequency in the patients. Due to the involvement of many other genes relating to the activity of Th1 cytokines, further studies are required to determine the molecular basis of the susceptibility to psoriasis. |
| Databáze: | OpenAIRE |
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