Uncoupling protein 2 gene (UCP2) 45-bp I/D polymorphism is associated with adiposity among Malaysian women
| Autor: | Zi-Lian Ban, Yogambigai Arumugam, Yee-How Say, Trishal Kaur, Sook-Ha Fan, Phee-Phee Chia, Mee-Lay Tan |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Biology Logistic regression Ion Channels General Biochemistry Genetics and Molecular Biology Mitochondrial Proteins Asian People Polymorphism (computer science) Internal medicine Genotype medicine Humans Uncoupling Protein 2 Allele Adiposity Genetics Malaysia General Medicine Odds ratio Anthropometry medicine.disease Obesity Minor allele frequency Endocrinology Female General Agricultural and Biological Sciences |
| Zdroj: | Journal of Biosciences. 39:867-875 |
| ISSN: | 0973-7138 0250-5991 |
| Popis: | This study investigated the association of Uncoupling Protein 2 gene (UCP2) 45-bp I/D polymorphism with obesity and adiposity in 926 Malaysian subjects (416 males;265 obese; 102/672/152 Malays/Chinese/Indians). The overall minor allele frequency (MAF) was 0.14, while MAFs according to Malay/Chinese/Indian were 0.17/0.12/0.21. The polymorphism was associated with ethnicity, obesity and overall adiposity (total body fat percentage, TBF), but not gender and central adiposity (waist-hip ratio, WHR). Gender- and ethnicity-stratified analysis revealed that within males, the polymorphism was not associated with ethnicity and anthropometric classes. However, within females, significantly more Indians, obese and those with high TBF carried I allele. Logistic regression analysis among females further showed the polymorphism was associated with obesity and overall adiposity; however, when adjusted for age and ethnicity, this association was abolished for obesity but remained significant for overall adiposity [Odds Ratio (OR) for ID genotype = 2.02 (CI=1.18, 3.45; p=0.01); I allele =1.81 (CI=1.15, 2.84; p=0.01)]. Indeed, covariate analysis controlling for age and ethnicity also showed that those carrying ID genotype or I allele had significantly higher TBF than the rest. In conclusion, UCP2 45-bp I/D polymorphism is associated with overall adiposity among Malaysian women. |
| Databáze: | OpenAIRE |
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