Distribution of PSA-NCAM in normal, Alzheimer’s and Parkinson’s disease human brain
| Autor: | Victoria F. Low, Clinton Turner, Richard L.M. Faull, Helen C. Murray, Molly E. V. Swanson, Maurice A. Curtis, Birger Dieriks |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Nervous system Cerebellum Parkinson's disease Blotting Western Caudate nucleus Fluorescent Antibody Technique Neural Cell Adhesion Molecule L1 Immunoenzyme Techniques 03 medical and health sciences Alzheimer Disease medicine Humans Aged Aged 80 and over Chemistry Polysialic acid General Neuroscience Brain Parkinson Disease Human brain Middle Aged Entorhinal cortex medicine.disease 030104 developmental biology medicine.anatomical_structure nervous system Sialic Acids Female Neural cell adhesion molecule Neuroscience |
| Zdroj: | Neuroscience. 330:359-375 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2016.06.003 |
| Popis: | Polysialated neural cell adhesion molecule (PSA-NCAM) is a membrane bound glycoprotein widely expressed during nervous system development. While commonly described in the neurogenic niches of the adult human brain, there is limited evidence of its distribution in other brain regions. PSA-NCAM is an important regulator of cell–cell interactions and facilitates cell migration and plasticity. Recent evidence suggests these functions may be altered in neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s disease (PD). This study provides a detailed description of the PSA-NCAM distribution throughout the human brain and quantitatively compares the staining load in cortical regions and sub-cortical structures between the control, AD and PD brain. Our results provide evidence of widespread, yet specific, PSA-NCAM expression throughout the human brain including regions devoid of PSA-NCAM in the rodent brain such as the caudate nucleus (CN) and cerebellum (CB). We also detected a significant reduction in PSA-NCAM load in the entorhinal cortex (EC) of cases that was inversely correlated with hyperphosphorylated tau load. These results demonstrate that PSA-NCAM-mediated structural plasticity may not be limited to neurogenic niches and is conserved in the aged brain. We also provide evidence that PSA-NCAM is reduced in the EC, a region severely affected by AD pathology. |
| Databáze: | OpenAIRE |
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