The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism
| Autor: | Lauren M. F. Merlo, Weidan Peng, James B. DuHadaway, James D. Montgomery, George C. Prendergast, Alexander J. Muller, Laura Mandik-Nayak |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Mice Knockout Mice Inbred BALB C Arthritis Immunology Autoimmunity Polymorphism Single Nucleotide Article Cell Line Mice Inbred C57BL Mice HEK293 Cells Antigens Neoplasm Core Binding Factor Alpha 2 Subunit Animals Guanine Nucleotide Exchange Factors Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Immunology and Allergy Gene Knock-In Techniques Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) Microtubule-Associated Proteins |
| Zdroj: | J Immunol |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.2100705 |
| Popis: | IDO2 is one of two closely related tryptophan catabolizing enzymes induced under inflammatory conditions. In contrast to the immunoregulatory role defined for IDO1 in cancer models, IDO2 has a proinflammatory function in models of autoimmunity and contact hypersensitivity. In humans, two common single-nucleotide polymorphisms have been identified that severely impair IDO2 enzymatic function, such that |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|