Effect of topical administration of tramadol on corneal wound healing in rats
| Autor: | Demet Sengul, Alparslan Apan, Selçuk Takır, Ozgun Cuvas Apan, Murat Atabey Özer |
|---|---|
| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı, Apan, Özgün Cuvaş |
| Rok vydání: | 2016 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty genetic structures Administration Topical Blepharospasm Fluorophotometry Cornea Tonometry Ocular 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Ophthalmology medicine Animals Corneal reflex Rats Wistar Intraocular Pressure Tramadol Wound Healing Slit Lamp Slit lamp Blinking business.industry eye diseases Rats Analgesics Opioid Disease Models Animal medicine.anatomical_structure Topical Anesthesia Administration Tramadol Hydrochloride sense organs Ophthalmic Solutions medicine.symptom business Wound healing 030217 neurology & neurosurgery Corneal Injuries medicine.drug |
| Zdroj: | International Ophthalmology. 36:675-680 |
| ISSN: | 1573-2630 0165-5701 |
| Popis: | Sengul, Ilker/0000-0001-5217-0755; OZER, MURAT ATABEY/0000-0003-1807-6911 WOS: 000383601800012 PubMed: 26820482 In this study, we aimed to investigate the effects of topical tramadol administration on corneal wound healing, and examine ophthalmic structures and intraocular pressure 7 days after tramadol administration. The experiments were conducted on eight male Wistar rats (250-300 g). After ophthalmic examination, epithelial cell layers in the central cornea were wounded. Rats received 30 mu L of tramadol hydrochloride in one eye (Group Tramadol) and the same volume of vehicle in the other (Group Control) every 12 h for 7 days. Both eyes were stained with fluorescein dye, photographed, and wound area was calculated every 8 h until complete healing was observed. Eye blink frequency and corneal reflex tests were measured before and after drug administrations. After 7 days, slit lamp biomicroscopy, fundoscopy, Goldmann applanation tonometry, and histological evaluation were performed. There was no difference in the corneal wound healing rates between the tramadol and control groups. Reduction in wound area over time was also similar; group-time interaction was insignificant (F = 738.911; p = 0.225). Tramadol application resulted in blinking and blepharospasm for 30 s, but vehicle did not. Corneal reflex was intact and eye blink frequency test results were similar in all measurement times in both groups. Slit lamp biomicroscopy, fundoscopy, and intraocular pressures were within normal range. Corneal cells appeared unaffected by the repeated doses of tramadol for 7 days. Topical tramadol application on the cornea did not cause any side effect, except for initial temporary blinking and blepharospasm. Corneal wound healing was not affected, either. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink