New fatty acid derivatives from Homaxinella sp., a marine sponge
| Autor: | Tayyab A. Mansoor, Bok Hee Bae, Jongki Hong, Chong O. Lee, Kwang Sik Im, Jee H. Jung |
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| Rok vydání: | 2005 |
| Předmět: |
Allylic rearrangement
Magnetic Resonance Spectroscopy Double bond Stereochemistry Antineoplastic Agents Fractionation Nuclear Overhauser effect Biochemistry Tumor Cells Cultured Animals Humans Molecule chemistry.chemical_classification Molecular Structure Chemical shift Fatty Acids Organic Chemistry Lysophosphatidylcholines Cell Biology Nuclear magnetic resonance spectroscopy Bromine Porifera chemistry Monoglycerides Drug Screening Assays Antitumor Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Lipids. 40:981-985 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-005-1459-0 |
| Popis: | Fractionation of the MeOH extract of Homaxinella sp., a marine sponge, led to the isolation of a sodium salt of a new brominated FA (1), two new MG (2 and 4), and a new lysoPC (6). The geometry of the double bonds in 1 and 2 was defined by comparison of the NMR chemical shifts of the allylic carbons, nuclear Overhauser effect spectroscopy correlations of the allylic protons, and coupling constants of the vinylic protons with those reported. Evidence mainly from NMR and MS analyses established the planar structures of the compounds. Compounds 1, 2, 4, and 6 were evaluated for cytotoxicity against a panel of five human solid tumor cell lines. Only compound 1 showed moderate activity. |
| Databáze: | OpenAIRE |
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