Short-Term Effects of Neoadjuvant Chemoradiotherapy on Internal Anal Sphincter Function
| Autor: | Neil Mortensen, Alison F. Brading, Jacopo Martellucci, Francesco Cetta, Bruno Lorenzi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer medicine.medical_treatment Urology Anal Canal In Vitro Techniques Arginine Internal anal sphincter Phenylephrine medicine Humans Neoadjuvant therapy Aged Aged 80 and over Rectal Neoplasms business.industry Abdominoperineal resection Gastroenterology Chemoradiotherapy General Medicine Middle Aged Anal canal medicine.disease Electric Stimulation Neoadjuvant Therapy medicine.anatomical_structure Case-Control Studies Sphincter Carbachol Female Sodium nitroprusside business medicine.drug |
| Zdroj: | Diseases of the Colon & Rectum. 55:465-472 |
| ISSN: | 0012-3706 |
| DOI: | 10.1097/dcr.0b013e31824154a0 |
| Popis: | Background Neoadjuvant chemoradiotherapy is recommended in the treatment of locally advanced rectal cancer. Studies have suggested that chemoradiotherapy adversely affects anorectal function. However, the functional implication and the underlying neuromyogenic changes involved in radiation-induced damage are poorly understood. Objective This study evaluated the functional changes following chemoradiotherapy on the internal anal sphincter. Design and patients This article describes an in vitro study on the internal anal sphincter collected from patients undergoing abdominoperineal resection or proctectomy. Five patients were treated by surgery alone (control group), and 6 received preoperative chemoradiotherapy (treatment group). Sphincter strips were mounted in organ bath, and the responses to electrical field stimulation and drugs were monitored. Settings The study was performed at the University of Oxford. Main outcome measures The end points of this study were to investigate whether chemoradiotherapy has any significant effects on internal anal sphincter function and, subsequently, to establish the type of injury induced. Results Chemoradiotherapy strips developed similar tone, but significantly lower spontaneous activity (p = 0.001) than controls. Electrical field stimulation induced relaxation, followed by contraction. At 50 Hz, electrical field stimulation produced 25.6 ± 4.9% (mean ± SE) of maximum relaxation followed by a contraction of 5.5 ± 0.9% of basal tone in chemoradiotherapy strips i9n comparison with 47.0 ± 6.2% (p = 0.009) and 17.7 ± 4.0% (p = 0.007) in controls. Relaxation was significantly attenuated by N-nitro-L-arginine. Significant differences were found in responses to carbachol (p = 0.018) and phenylephrine (p = 0.022), but not to sodium nitroprusside. Limitations This work was limited by the relatively small number of patients enrolled, because of the difficulty of finding human tissue for laboratory studies, and the lack of long-term results. Conclusions Chemoradiotherapy significantly impairs internal anal sphincter function and intrinsic nerves seem more susceptible than smooth muscle. The exclusion of anal canal from the radiation field is recommended, when oncologically safe. |
| Databáze: | OpenAIRE |
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