Vitamin D-binding protein as a biomarker to confirm specific clinical diagnoses
| Autor: | Barbara Lisowska-Myjak, Aleksandra Jóźwiak-Kisielewska, Ewa Skarżyńska, Jacek Łukaszkiewicz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
0301 basic medicine Vitamin Vitamin D-binding protein Inflammation Bioinformatics Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Genetics Vitamin D and neurology Humans Medicine Renal Insufficiency cardiovascular diseases Acute-Phase Reaction Molecular Biology business.industry Vitamin D-Binding Protein Acute-phase protein Transport protein Biomarker (cell) 030104 developmental biology chemistry 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom business Biomarkers circulatory and respiratory physiology |
| Zdroj: | Expert Review of Molecular Diagnostics. 20:49-56 |
| ISSN: | 1744-8352 1473-7159 |
| Popis: | Introduction: Vitamin D-binding protein (DBP) performs a variety of functions as a transporter for various ligands and takes part in a number of systemic and local physiological and pathological processes. The knowledge about the pathomechanisms of this protein involvement justifies its use as a biomarker to confirm specific clinical diagnoses suggested by nonspecific signs and symptoms.Areas covered: DBP has properties of both systemic laboratory parameters measured in the blood plasma and specific parameters measured in variety of physiological fluids to assess local changes in specific body organs. Articles published in English between 1993 and 2019 were searched for in PubMed using terms DBP, vitamin D, and metabolites, inflammation. DBP is a transport protein and a regulator of immune and inflammatory processes.Expert opinion: DBP capacity for transporting numerous ligands and co-involvement of DBP in immune and inflammatory processes suggest that DBP may be used in laboratory diagnostics as a specific parameter to confirm pathomechanisms of several systemic diseases and local conditions. Changes in the concentration of DBP present in a variety of clinical material may provide valuable information for use in assessing the severity and treatment of pathological processes. |
| Databáze: | OpenAIRE |
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