Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis
| Autor: | Edmundo Pessoa de Almeida Lopes, Liana Gonçalves-Macedo, Carlos Feitosa Luna, Ana Lúcia Coutinho Domingues, Vitor Gomes Mota, Brivaldo Markman Filho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Liver Cirrhosis Male medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine Cirrhosis lcsh:RC955-962 lcsh:QR1-502 Schistosomiasis oesophageal and gastric varices Gastroenterology lcsh:Microbiology 03 medical and health sciences Liver disease 0302 clinical medicine Model for End-Stage Liver Disease Internal medicine schistosomiasis neglected diseases hepatopulmonary syndrome medicine Prevalence Humans Prospective Studies Hepatopulmonary syndrome medicine.diagnostic_test integumentary system business.industry ultrasound portal hypertension Articles Middle Aged medicine.disease Schistosomiasis mansoni Endoscopy 030104 developmental biology Cross-Sectional Studies Concomitant Portal hypertension 030211 gastroenterology & hepatology Female business |
| Zdroj: | Memórias do Instituto Oswaldo Cruz Memórias do Instituto Oswaldo Cruz, Volume: 112, Issue: 7, Pages: 469-473, Published: JUL 2017 Memórias do Instituto Oswaldo Cruz., Vol 112, Iss 7, Pp 469-473 |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | BACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those with portal hypertension without liver cirrhosis, as may occur in hepatosplenic schistosomiasis (HSS). OBJECTIVES To investigate the prevalence of HPS in patients with HSS, and to determine whether the occurrence of HPS is influenced by concomitant cirrhosis. METHODS We evaluated patients with HSS with or without concomitant liver cirrhosis. All patients underwent laboratory testing, ultrasound, endoscopy, contrast echocardiography, and arterial blood gas analysis. FINDINGS Of the 121 patients with HSS, 64 were also diagnosed with liver cirrhosis. HPS was diagnosed in 42 patients (35%) and was more frequent among patients with concomitant liver cirrhosis than in those without cirrhosis (42% vs. 26%), but the difference was not significant (p = 0.069). HPS was more common in those with spider naevi, Child-Pugh classes B or C and high model for end stage liver disease (MELD) scores (p < 0.05 each). MAIN CONCLUSIONS The prevalence of HPS was 35% in this study. The occurrence of liver cirrhosis concomitantly with HSS may have influenced the frequency of patients presenting with HPS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|