Effect of Delivery Mode and Nutrition on Gut Microbiota in Neonates
| Autor: | Kazunari Kaneko, Shohei Akagawa, Sohsaku Yamanouchi, Atsushi Ohashi, Atsushi Akane, Yuko Akagawa, Mitsuru Yamagishi, Shin-ichiro Sekiya, Chikushi Onuma, Masaki Hashiyada, Tadashi Yamaguchi, Takahisa Kimata, Shoji Tsuji |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Enterobacteriales Male medicine.medical_treatment Breastfeeding Medicine (miscellaneous) Physiology 030209 endocrinology & metabolism Gut flora Breast milk 03 medical and health sciences 0302 clinical medicine Japan RNA Ribosomal 16S medicine Humans Caesarean section 030109 nutrition & dietetics Nutrition and Dietetics biology Bacteria Lactobacillales business.industry Cesarean Section Infant Newborn biology.organism_classification Delivery mode medicine.disease Delivery Obstetric Infant Formula Gastrointestinal Microbiome Breast Feeding Vagina Dysbiosis Female business |
| Zdroj: | Annals of nutritionmetabolism. 74(2) |
| ISSN: | 1421-9697 |
| Popis: | Background/Aims: The mode of delivery (vaginal or cesarean section) and feeding type (breastfeeding or formula feeding) of neonates are considered the most influential factors in the development of gut microbiota. Objectives: This study investigated the effect of prebiotic-rich breast milk on overcoming gut microbiota dysbiosis. Method: Stool samples from 36 healthy Japanese neonates were obtained at 4 days and 1 month of age, and divided into 4 groups based on mode of delivery and feeding type. The gut microbiota composition and bacterial diversity were assessed using 16S rRNA sequencing. Results: At 4 days old, vaginally delivered neonates had a significantly higher diversity of bacteria than those born by cesarean section. Bacteroidales and Enterobacteriales were overrepresented in vaginally delivered neonates (p = 0.0031 and p = 0.011), while Bacillales and Lactobacillales were overrepresented in caesarean section delivered neonates (p = 0.012 and p = 0.0016). However, there was little difference in bacterial diversity and bacterial relative abundance at 1 month of age between groups. Conclusions: Cesarean section delivery appeared to reduce the diversity of neonate gut microbiota, resulting in dysbiosis, but this improved to the equivalent level seen in vaginally delivered infants by 1 month of age. Breastfeeding, even for short periods, may therefore improve neonate gut dysbiosis. |
| Databáze: | OpenAIRE |
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