Association between serological evidence of past Coxiella burnetii infection and atherosclerotic cardiovascular disease in elderly patients
| Autor: | M.J. Mora-Simón, A. Martin-Ezquerro, S. González-Quijada |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Congenital cytomegalovirus infection Fluorescent Antibody Technique Q fever Coxiella burnetii Disease Gastroenterology Serology cardiovascular disease Internal medicine Diabetes mellitus Atherosclerotic disease medicine Humans Serologic Tests Aged Aged 80 and over biology business.industry Atrial fibrillation General Medicine Atherosclerosis medicine.disease biology.organism_classification Antibodies Bacterial Infectious Diseases Cardiovascular Diseases Spain Q fever serology Case-Control Studies Immunoglobulin G Immunology biology.protein Female Antibody Q Fever business |
| Zdroj: | Clinical Microbiology and Infection. 20(9):873-878 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/1469-0691.12541 |
| Popis: | Q fever, caused by Coxiella burnetii, may cause vascular complications, but the role that this infection may play in the development of atherosclerotic cardiovascular disease remains unknown. This study examined the association between Q fever serology and cardiovascular disease in a region where Q fever is endemic. A case-control study was conducted in the Hospital Universitario de Burgos (Spain) between February 2011 and June 2012. A total of 513 samples were tested, from 454 hospitalized patients ≥65 years old, of whom 164 were cases (patients with prevalent or incident coronary heart, cerebrovascular or peripheral artery, disease) and 290 controls (patients without cardiovascular disease). Serum IgG antibody phase II titres against Q fever were determined by immunofluorescence assay. Seropositivity (titres ≥1:256) was detected in 84/164 (51.2%) cases and in 109/290 (37.6%) controls (p = 0.005; OR, 1.7; 95% CI, 1.1–2.5). This ratio increases when adjusted for sex, hypertension, dyslipidaemia, smoking, diabetes and atrial fibrillation (OR, 2.6; 95% CI, 1.5–4.7). The geometric mean titre (GMT) for C. burnetii phase II assay was higher in cases than in controls (p = 0.004). We found no significant relationship between cardiovascular disease and C. pneumoniae , and Cytomegalovirus seropositivity (both determined by the IgG ELISA method). In conclusion, serological evidence of past Q fever is associated with atherosclerotic cardiovascular disease in elderly patients in an endemic region. |
| Databáze: | OpenAIRE |
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