Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing’s Disease – Analysis from the DPV Database
| Autor: | Katharina Warncke, Dominik Bergis, Peter H. Kann, Sebastian Wernert, Esther Bollow, Sebastian Kummer, Reinhard W. Holl, Michael Hummel, Flavius Zoicas |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Risk 0301 basic medicine Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Comorbidity Disease Type 2 diabetes Diabetes Therapy Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Acromegaly Internal Medicine medicine Humans Hypoglycemic Agents Insulin Longitudinal Studies Registries Pituitary ACTH Hypersecretion Aged Dyslipidemias Type 1 diabetes business.industry General Medicine Cushing's disease Middle Aged medicine.disease Europe Diabetes Mellitus Type 1 030104 developmental biology Diabetes Mellitus Type 2 Hypertension Female business |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 128:104-110 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/a-0600-9649 |
| Popis: | Background Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. Methods Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9.4. Results Patients with diabetes and acromegaly (n=52) or Cushing’s disease (n=15) were significantly younger at diabetes onset (median age 50.1 and 45.0 vs. 59.0 years in type 2 diabetes; both p Conclusion Patients with acromegaly are at a high risk for cardiovascular disease, reflected by dyslipidemia and hypertension. A high proportion of patients with diabetes in acromegaly or Cushing´s disease receives insulin. Based on a multicenter register, a sufficient number of patients with rare forms of diabetes can be analyzed. |
| Databáze: | OpenAIRE |
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