Nuclear transport factor directs localization of protein synthesis during mitosis
| Autor: | Geert van den Bogaart, Bert Poolman, Liesbeth M. Veenhoff, Anne C. Meinema, Victor V. Krasnikov |
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| Přispěvatelé: | Optical Physics of Condensed Matter, Enzymology, Molecular Neuroscience and Ageing Research (MOLAR) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Cytoplasm
Nucleocytoplasmic Transport Proteins Saccharomyces cerevisiae Proteins Cell division Active Transport Cell Nucleus Mitosis REQUIREMENT Saccharomyces cerevisiae Biology Karyopherins Models Biological BINDING-PROTEINS SACCHAROMYCES-CEREVISIAE Transcription (biology) Gene Expression Regulation Fungal Protein biosynthesis YEAST RNA Messenger LIVING CELLS Karyopherin chemistry.chemical_classification Cell Nucleus Messenger RNA IMPORT RNA-Binding Proteins Cell Biology beta Karyopherins EXPORT Cell biology Protein Transport chemistry MESSENGER-RNA TRANSLATION NAB2P MOBILITY Protein Biosynthesis Nuclear transport |
| Zdroj: | Nature Cell Biology, 11(3), 350-U269. Nature Publishing Group |
| ISSN: | 1476-4679 1465-7392 |
| Popis: | Export of messenger RNA from the transcription site in the nucleus and mRNA targeting to the translation site in the cytoplasm are key regulatory processes in protein synthesis. In yeast, the mRNA-binding proteins Nab2p and Nab4p/Hrp1p accompany transcripts to their translation site, where the karyopherin Kap104p mediates both their dissociation from the mRNA and their transport back into the nucleus. We found that Kap104p localized to the distal bud tip and the bud neck during cell division, resulting in a localized release of translation-competent mRNA and increased protein synthesis in the emerging daughter cell. Temporally and spatially coordinated localization of Kap104p is a new mechanism for the asymmetric distribution of protein synthesis in dividing cells. |
| Databáze: | OpenAIRE |
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