The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons
| Autor: | Giuseppe Lippi, Rosalia Aloe, F. De Vita, Marcello Maggio, Fulvio Lauretani, Graziano Ceresini, A. Vignali, G. Schiavi, Stefania Bandinelli, Luigi Ferrucci, Mm McDermott, R. Volpi, Francesco Giallauria, Andrea Artoni, Gian Paolo Ceda, C. Cattabiani |
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| Přispěvatelé: | Maggio, M., Cattabiani, C., Lauretani, F., Artoni, A., Bandinelli, S., Schiavi, G., Vignali, A., Volpi, R., Ceresini, G., Lippi, G., Aloe, R., De Vita, F., Giallauria, F., Mcdermott, M. M., Ferrucci, L., Ceda, G. P. |
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging Cross-sectional study Older person Comorbidity Sex Factor Disease Sex hormone-binding globulin Risk Factors Sex Hormone-Binding Globulin Age Factor Testosterone Sex hormones Aged 80 and over Estradiol biology Age Factors Up-Regulation Italy Female Cardiology and Cardiovascular Medicine Human medicine.medical_specialty Logistic Model Down-Regulation Older persons PAD SHBG Article Peripheral Arterial Disease Sex Factors Diabetes mellitus Internal medicine medicine Humans Ankle Brachial Index Sex hormone Aged Cross-Sectional Studie Chi-Square Distribution business.industry Risk Factor Biomarker medicine.disease Cross-Sectional Studies Logistic Models Endocrinology biology.protein Metabolic syndrome business Biomarkers Hormone |
| Zdroj: | Atherosclerosis. 225:469-474 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2012.09.014 |
| Popis: | OBJECTIVES: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects without heart disease. DESIGN: The relationship between concentrations of 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease. RESULTS: Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL(-1) ; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D < 20 ng mL(-1) ]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, P < 0.05) and LV mass index (β 7.5, SE 2.6, P < 0.01). A significant nonlinear relation between 25(OH)D and LV concentric remodelling was observed. LV remodelling was more likely in participants with 25(OH)D levels |
| Databáze: | OpenAIRE |
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