Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1
| Autor: | Sudeepta Aggarwal, H. A. Sharma, Sudhir Gupta, Larry D. Byers, Sastry Gollapudi, H. E. Ensley |
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| Rok vydání: | 1995 |
| Předmět: |
Glycoside Hydrolases
Cell Survival Lymphocyte T cell T-Lymphocytes Biophysics HIV Core Protein p24 HIV Infections Biology In Vitro Techniques Polysaccharide Lymphocyte Activation Virus Replication Biochemistry Peripheral blood mononuclear cell Antiviral Agents Cell Fusion Polysaccharides medicine Humans Molecular Biology chemistry.chemical_classification Syncytium Plants Medicinal virus diseases Cell Biology Molecular biology medicine.anatomical_structure chemistry Toxicity Officinalis CD8 |
| Zdroj: | Biochemical and biophysical research communications. 210(1) |
| ISSN: | 0006-291X |
| Popis: | A polysaccharide (MAR-10) was isolated from the aqueous extract of the plant Hyssop officinalis and examined for its activity against HIV-1 (SF strain) in HUT78 T cell line and primary cultures of peripheral blood mononuclear cells. MAR-10, in a concentration-dependent manner, inhibited HIV-1 replication as demonstrated by the inhibition of HIV-1 p24 antigen and syncytia formation. Furthermore, MAR-10 had no significant direct toxicity or effect on lymphocyte functions or CD4+ and CD8+ T cell counts. In addition, MAR-10 has broad spectrum anti-glycosidase activity. Our study demonstrates that MAR-10 contains strong anti-HIV-1 activity that may be useful in the treatment of patients with HIV-1 infection. |
| Databáze: | OpenAIRE |
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