Antiphospholipid Syndrome During Septic Shock: Hyper- or Hypocoagulability?: A Case Report
Autor: | Francesco Dentali, Mark Crowther, Nicoletta Barzaghi, Fulvio Pomero, Emanuele Rezoagli |
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Přispěvatelé: | Rezoagli, E, Barzaghi, N, Crowther, M, Dentali, F, Pomero, F |
Rok vydání: | 2019 |
Předmět: |
Ischemia
Fatal Outcome Antiphospholipid syndrome Anticoagulants Blood Coagulation Blood Coagulation Disorders Cellulitis Extremities Female Heparin Humans Middle Aged Antiphospholipid Syndrome Shock Septic Thrombelastography medicine In patient Blood Coagulation Disorder medicine.diagnostic_test business.industry Septic shock Septic Anticoagulant Shock General Medicine medicine.disease Thromboelastography Discontinuation Anesthesia business Extremitie medicine.drug Celluliti Human |
Zdroj: | AA practice. 13(8) |
ISSN: | 2575-3126 |
Popis: | We report the clinical case of a septic patient with antiphospholipid syndrome who developed ischemia in all 4 limbs, despite a normal systemic blood pressure. Prolonged coagulation times suggested a hemorrhagic diathesis, requiring transfusion of fresh-frozen plasma and discontinuation of heparin infusion. In contrast, the study of the viscoelastic properties of the clot by thromboelastography suggested an uncontrolled activation of the coagulation cascade. This observation led to the reintroduction of heparin with improvement in the patient's laboratory findings. Anesthesiologists should consider thromboelastography to correct coagulopathies in patients with septic shock in the presence of antiphospholipid antibodies. |
Databáze: | OpenAIRE |
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