The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage
| Autor: | Weiming Li, Ziping Zhang, Curt Wilkerson, Hong Wu, Kevin M. Carr, John H. Teeter, Scot V. Libants, Yu Wen Chung-Davidson |
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| Rok vydání: | 2009 |
| Předmět: |
DNA
Complementary Evolution Pseudogene Chordate Receptors Odorant Genome Evolution Molecular 03 medical and health sciences 0302 clinical medicine biology.animal QH359-425 Animals Gene family Petromyzon Gene Phylogeny Ecology Evolution Behavior and Systematics 030304 developmental biology Genetics Life Cycle Stages 0303 health sciences biology Lamprey Computational Biology Vertebrate Sequence Analysis DNA biology.organism_classification Receptors Glutamate Multigene Family Receptors Calcium-Sensing 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Evolutionary Biology, Vol 9, Iss 1, p 180 (2009) BMC Evolutionary Biology |
| ISSN: | 1471-2148 |
| DOI: | 10.1186/1471-2148-9-180 |
| Popis: | Background In gnathostomes, chemosensory receptors (CR) expressed in olfactory epithelia are encoded by evolutionarily dynamic gene families encoding odorant receptors (OR), trace amine-associated receptors (TAAR), V1Rs and V2Rs. A limited number of OR-like sequences have been found in invertebrate chordate genomes. Whether these gene families arose in basal or advanced vertebrates has not been resolved because these families have not been examined systematically in agnathan genomes. Results Petromyzon is the only extant jawless vertebrate whose genome has been sequenced. Known to be exquisitely sensitive to several classes of odorants, lampreys detect fewer amino acids and steroids than teleosts. This reduced number of detectable odorants is indicative of reduced numbers of CR gene families or a reduced number of genes within CR families, or both, in the sea lamprey. In the lamprey genome we identified a repertoire of 59 intact single-exon CR genes, including 27 OR, 28 TAAR, and four V1R-like genes. These three CR families were expressed in the olfactory organ of both parasitic and adult life stages. Conclusion An extensive search in the lamprey genome failed to identify potential orthologs or pseudogenes of the multi-exon V2R family that is greatly expanded in teleost genomes, but did find intact calcium-sensing receptors (CASR) and intact metabotropic glutamate receptors (MGR). We conclude that OR and V1R arose in chordates after the cephalochordate-urochordate split, but before the diversification of jawed and jawless vertebrates. The advent and diversification of V2R genes from glutamate receptor-family G protein-coupled receptors, most likely the CASR, occurred after the agnathan-gnathostome divergence. |
| Databáze: | OpenAIRE |
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