Suzuki-Miyaura cross-coupling of potassium alkoxyethyltrifluoroborates: access to aryl/heteroarylethyloxy motifs

Autor: Frederik Jan Rita Rombouts, Nicolas Fleury-Brégeot, Daniel Oehlrich, Floriane Beaumard, Marc Presset, Gary A. Molander, Virginie Colombel
Rok vydání: 2012
Předmět:
Zdroj: The Journal of organic chemistry. 77(22)
ISSN: 1520-6904
Popis: The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.
Databáze: OpenAIRE