Induction of aortic lipid deposition in a high-response (ExHC) rat fed a diet containing cholesterol and cholic acid
| Autor: | Yoshio Imai, Akio Shino, Haruki Matsumura, Kiyoko Oka, Ziro Suzuoki |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
medicine.medical_specialty Intimal hyperplasia Hypercholesterolemia Cholesterol Dietary chemistry.chemical_compound Sex Factors Plasma cholesterol Internal medicine medicine.artery medicine Animals Lipid deposition Sodium Cholate Aorta Phospholipids Triglycerides Cholesterol Cholic acid Cholic Acids Rats Inbred Strains medicine.disease Lipids Rats Endocrinology Liver chemistry Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Olive oil |
| Zdroj: | Atherosclerosis. 28:453-461 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(77)90072-7 |
| Popis: | Male ExHC and Sprague--Dawley rats were fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil for 16 weeks. The ExHC rat is highly susceptible to dietary hypercholesterolemia. Aortas of the ExHC rats showed Sudan-stained deposits and cholesterol accumulation in the intima and media, whereas no deposited lipids were seen in those of the Sprague--Dawley rats. In male and female ExHC rats fed diets containing the above supplements at 3 dose levels, plasma cholesterol and aortic lipid deposition were found to be dose-dependent. Lipid deposition was more prominent in female than in males, but aortic intimal proliferation was absent. |
| Databáze: | OpenAIRE |
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