Prevention of human adenocarcinoma with CpG-ODN in a mouse model
| Autor: | Sanjay K. Srivastava, Stephen E Wright, Jewel Ahmed, Nazrul I. Chowdhury, Kathleen Rewers-Felkins |
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| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Innate immune system business.industry Innate lymphoid cell CCL18 Lymphokine hemic and immune systems Articles Immune receptor biochemical phenomena metabolism and nutrition respiratory system Acquired immune system medicine.anatomical_structure Immune system Oncology Immunology bacteria Medicine business B cell |
| Zdroj: | Oncology Letters. 4:1061-1063 |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2012.849 |
| Popis: | CpG-ODNs activate various immune cell subsets and induce the production of numerous cytokines. To determine whether a CpG-ODN-activated innate immune system, without the adaptive immune system, was capable of protecting against cancer cell growth, NOD/SCID mice, which do not have T or B cell function but have a functional innate immune system, were used as a model system. NOD/SCID mice were injected subcutaneously with human prostate cancer cells followed by subcutaneous injection of incremental doses of CpG-ODNs. CpG-ODNs displayed a dose-related antitumoral effect leading to the prevention of tumor growth. These results indicate that ODNs are capable of activating the innate immune system and destroying human cancer cells in the absence of the adaptive immune system. |
| Databáze: | OpenAIRE |
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