Catching HPV in the Homologous Recombination Cookie Jar
| Autor: | Nicholas A. Wallace |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
DNA Repair DNA repair Uterine Cervical Neoplasms Alphapapillomavirus Biology Microbiology 03 medical and health sciences Virology Gene expression medicine Humans Human papillomavirus Homologous Recombination 030304 developmental biology Cervical cancer 0303 health sciences 030306 microbiology Papillomavirus Infections Head and neck cancer Oncogenes Cell cycle medicine.disease Homologous Recombination Pathway Infectious Diseases Host-Pathogen Interactions Cancer research Female Homologous recombination DNA Damage Signal Transduction |
| Zdroj: | Trends in Microbiology. 28:191-201 |
| ISSN: | 0966-842X |
| DOI: | 10.1016/j.tim.2019.10.008 |
| Popis: | To replicate, the human papillomaviruses (HPVs) that cause anogenital and oropharyngeal malignancies must simultaneously activate DNA repair pathways and avoid the cell cycle arrest that normally accompanies DNA repair. For years it seemed that HPV oncogenes activated the homologous recombination pathway to facilitate the HPV lifecycle. However, recent developments show that, although homologous recombination gene expression and markers of pathway activation are increased, homologous recombination itself is attenuated. This review provides an overview of the diverse ways that HPV oncogenes manipulate homologous recombination and ideas on how the resulting dysregulation and inhibition offer opportunities for improved therapies and biomarkers. |
| Databáze: | OpenAIRE |
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