Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes

Autor: Viviane Rodrigues Tavares, Sheila Araújo Teles, Marcia Dias, Renata Ferreira, Clara F. T. Yoshida, Selma A. Gomes, Regina Maria Bringel Martins, Simonne Almeida e Silva
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
HBsAg
medicine.medical_treatment
lcsh:QR1-502
medicine.disease_cause
Polymerase Chain Reaction
lcsh:Microbiology
Serology
law.invention
Risk Factors
law
Genotype
Prevalence
Medicine
Child
Polymerase chain reaction
Aged
80 and over
education.field_of_study
hemodialysis
virus diseases
Middle Aged
Hepatitis B
Child
Preschool
Female
Hemodialysis
Restriction fragment length polymorphism
Brazil
Polymorphism
Restriction Fragment Length
Adult
Microbiology (medical)
Central Brazil
lcsh:Arctic medicine. Tropical medicine
Adolescent
lcsh:RC955-962
Population
Enzyme-Linked Immunosorbent Assay
Renal Dialysis
Humans
Hepatitis B Antibodies
education
Aged
Hepatitis B virus
Hepatitis B Surface Antigens
business.industry
Virology
digestive system diseases
DNA
Viral
Multivariate Analysis
business
hepatitis B virus
Biomarkers
Zdroj: Memórias do Instituto Oswaldo Cruz., Vol 101, Iss 6, Pp 689-692 (2006)
Memórias do Instituto Oswaldo Cruz, Volume: 101, Issue: 6, Pages: 689-692, Published: SEP 2006
ISSN: 1678-8060
0074-0276
Popis: Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8% (95% CI: 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4% (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5%) was predominant, followed by A (30.8%), while genotype F was detected in only one (7.7%) sample.
Databáze: OpenAIRE
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