Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes
Autor: | Viviane Rodrigues Tavares, Sheila Araújo Teles, Marcia Dias, Renata Ferreira, Clara F. T. Yoshida, Selma A. Gomes, Regina Maria Bringel Martins, Simonne Almeida e Silva |
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Jazyk: | angličtina |
Rok vydání: | 2006 |
Předmět: |
Male
HBsAg medicine.medical_treatment lcsh:QR1-502 medicine.disease_cause Polymerase Chain Reaction lcsh:Microbiology Serology law.invention Risk Factors law Genotype Prevalence Medicine Child Polymerase chain reaction Aged 80 and over education.field_of_study hemodialysis virus diseases Middle Aged Hepatitis B Child Preschool Female Hemodialysis Restriction fragment length polymorphism Brazil Polymorphism Restriction Fragment Length Adult Microbiology (medical) Central Brazil lcsh:Arctic medicine. Tropical medicine Adolescent lcsh:RC955-962 Population Enzyme-Linked Immunosorbent Assay Renal Dialysis Humans Hepatitis B Antibodies education Aged Hepatitis B virus Hepatitis B Surface Antigens business.industry Virology digestive system diseases DNA Viral Multivariate Analysis business hepatitis B virus Biomarkers |
Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 101, Iss 6, Pp 689-692 (2006) Memórias do Instituto Oswaldo Cruz, Volume: 101, Issue: 6, Pages: 689-692, Published: SEP 2006 |
ISSN: | 1678-8060 0074-0276 |
Popis: | Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8% (95% CI: 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4% (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5%) was predominant, followed by A (30.8%), while genotype F was detected in only one (7.7%) sample. |
Databáze: | OpenAIRE |
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