Hypoxia preconditioning elicit differential response in tissue-specific MSCs via immunomodulation and exosomal secretion

Autor:	Suchi Gupta, Sonali Rawat, Vishnu Krishnakumar, E. Pranshu Rao, Sujata Mohanty
Rok vydání:	2021
Předmět:	Immunomodulation Histology Humans Cell Differentiation Mesenchymal Stem Cells Cell Biology Wharton Jelly Hypoxia Cells Cultured Pathology and Forensic Medicine Cell Proliferation
Zdroj:	Cell and tissue research. 388(3)
ISSN:	1432-0878
Popis:	Mesenchymal stromal cells (MSCs) are emerging as an ideal candidate for regenerative medicine. It is known that the culture conditions impact the cellular properties of MSCs and their therapeutic behavior. Moreover, maintenance of MSCs in low oxygen tension for a short duration has shown to be beneficial for MSCs as it is similar to that of their physiological niche. However, the precise mechanism through which hypoxia pre-conditioning affects MSCs is not clear yet. Thus, in this study, we have investigated the effect of hypoxia exposure (1% O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d0c8f3d212cd5e51a6ca392a2b633c https://pubmed.ncbi.nlm.nih.gov/35316374 Zobrazit plný text záznamu Full text from SpringerLink