LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation
| Autor: | Lei Zheng, Li Ding, Yu-Neng Hua, Xiao-Min Lin, Ru-Yi Zhang, Xin He, Jun-Jiang Chen, Bao-Hong Ping, Biao Yang, Qian Wang, Chang-Meng Wu, Xiumei Hu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2 Vascular smooth muscle Myocytes Smooth Muscle Down-Regulation Biology Models Biological Muscle Smooth Vascular 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Heterogeneous-Nuclear Ribonucleoprotein Group A-B Genetics Humans Molecular Biology Cell Proliferation Cell growth Angiotensin II Cell Biology General Medicine Plaque Atherosclerotic Long non-coding RNA In vitro 030104 developmental biology Gene Knockdown Techniques 030220 oncology & carcinogenesis Vascular Disorder Cancer research RNA Long Noncoding Function (biology) |
| Zdroj: | DNA and Cell Biology. 40:652-661 |
| ISSN: | 1557-7430 1044-5498 |
| DOI: | 10.1089/dna.2020.6451 |
| Popis: | The abnormal proliferation of vascular smooth muscle cells (VSMCs) is crucial in the atherosclerosis. Although long noncoding RNAs (lncRNAs) are implicated in a variety of diseases, their roles in activation of VSMCs proliferation and vascular disorder diseases are not well understood. In addition, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) was reported to participate in lncRNAs-mediated function. Herein, we propose to investigate the role of lncRNA AC105942.1 and hnRNPA2/B1 in pathological VSMCs proliferation and the possible mechanisms in vitro. We have identified that lncRNA AC105942.1 was downregulated and hnRNPA2/B1 was upregulated in atherosclerotic plaques compared with normal artery tissues. Enhanced lncRNA AC105942.1 could noticeably inhibit Ang II-induced VSMCs proliferation. Further investigation suggested that lncRNA AC105942.1 could downregulate the expression of hnRNPA2/B1 and then regulate the level of CDK4 and p27. Taken together, our study indicated that lncRNA AC105942.1 downregulated hnRNPA2B1 to protect against the atherosclerosis by suppressing VSMCs proliferation. LncRNA AC105942.1 and hnRNPA2/B1 could represent potential therapeutic and diagnostic targets to atherosclerosis-related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|