Cytogenetic analysis of peripheral blood lymphocytes, many years after exposure of workers to low-dose ionizing radiation
| Autor: | Xi'ai Wang, Fengling Zhao, Ping Wang, Lin Han, Bao-hua Fu, Quan-Fu Sun, Fei Guo, Yu-min Lü |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors Health Toxicology and Mutagenesis Physiology Chromosomal translocation Biology Radiation Dosage Ionizing radiation Toxicology Dicentric chromosome Occupational Exposure Radiation Ionizing Genetics Humans Lymphocytes Irradiation Cells Cultured Aged Chromosome Aberrations Micronucleus Tests Low dose Middle Aged Peripheral blood Case-Control Studies Cytogenetic Analysis Micronucleus test Micronucleus |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 771:1-5 |
| ISSN: | 1383-5718 |
| DOI: | 10.1016/j.mrgentox.2014.06.003 |
| Popis: | The present study aims to measure chromosomal aberrations and micronuclei in peripheral blood lymphocytes from 25 subjects exposed to 0.10-0.33 Gy external or internal irradiation 32-41 years ago using conventional cytogenetic analysis methods. The frequencies of total chromosome-type aberrations and micronucleus significantly increased in the exposed group compared with that in age-matched control group (p0.001); chromatid-type aberrations showed no difference between the two groups (p0.05). When exposed subjects were divided into two groups based on exposure dose, higher levels of dicentric plus translocation frequencies were observed in the ≥0.15 Gy dose group compared with those in the0.15 Gy dose group, though the difference was not significant. Borderline association between exposure dose and dicentric frequency was detected in the exposed group (r=0.358; p=0.079). These results suggest that the genotoxic effects of ionizing radiation remain in subjects exposed to low-dose radiation even decades after exposure. |
| Databáze: | OpenAIRE |
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