Adipose oxidative stress and protein carbonylation
| Autor: | David A. Bernlohr, Ann V. Hertzel, Yimao Huang, Amy K. Hauck |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Protein Carbonylation Adipose tissue medicine.disease_cause Biochemistry 03 medical and health sciences chemistry.chemical_compound Insulin resistance Lipid oxidation Adipocyte Internal medicine medicine Animals Humans Molecular Biology chemistry.chemical_classification Reactive oxygen species 030102 biochemistry & molecular biology Endoplasmic reticulum JBC Reviews Proteins Cell Biology medicine.disease Oxidative Stress 030104 developmental biology Endocrinology chemistry Adipose Tissue Reactive Oxygen Species Oxidative stress |
| Popis: | Increased oxidative stress and abundance of reactive oxygen species (ROS) are positively correlated with a variety of pathophysiologies, including cardiovascular disease, type 2 diabetes, Alzheimer's disease, and neuroinflammation. In adipose biology, diabetic obesity is correlated with increased ROS in an age- and depot-specific manner and is mechanistically linked to mitochondrial dysfunction, endoplasmic reticulum (ER) stress, potentiated lipolysis, and insulin resistance. The cellular quality control systems that homeostatically regulate oxidative stress in the lean state are down-regulated in obesity as a consequence of inflammatory cytokine pressure leading to the accumulation of oxidized biomolecules. New findings have linked protein, DNA, and lipid oxidation at the biochemical level, and the structures and potential functions of protein adducts such as carbonylation that accumulate in stressed cells have been characterized. The sum total of such regulation and biochemical changes results in alteration of cellular metabolism and function in the obese state relative to the lean state and underlies metabolic disease progression. In this review, we discuss the molecular mechanisms and events underlying these processes and their implications for human health and disease. |
| Databáze: | OpenAIRE |
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