Estrogen induces estrogen receptor α expression and hepatocyte proliferation in late pregnancy
| Autor: | Yoji Tsugawa, Takeshi Imai, Masaki Hiramoto |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Biophysics Estrogen receptor Partial hepatectomy Conditional mutagenesis Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine Animals Molecular Biology Cell Proliferation Mice Knockout Chemistry Estrogen Receptor alpha Estrogens Cell Biology medicine.disease Late pregnancy Up-Regulation Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology Estrogen 030220 oncology & carcinogenesis Hepatocyte Hepatocytes Female Estrogen receptor alpha hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemical and Biophysical Research Communications. 511:592-596 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2019.02.119 |
| Popis: | Partial hepatectomy (PH) induces estradiol production, and then hepatocyte proliferation. Estradiol may play a role in triggering hepatocyte proliferation after PH. In this study, estradiol was injected to the Estrogen Receptor alpha (ERα) or ERβ KO mice. No increased hepatocyte proliferation was observed in ERα KO mice, indicates that ERα is involved in estradiol-induced hepatocyte proliferation. The ERα and ERβ KO mice are sterile, hence it is impossible to study ERα and ERβ function during pregnancy when the estrogen levels are highest. Using conditional mutagenesis technique, we made ERα hepatocyte KO mice, which are fertile. We used these mice for analyzing the hepatocyte ERα function during pregnancy. However, in the control mice, the maternal hepatocyte was proliferated higher in late pregnancy, but no pregnancy-induced hepatocyte proliferation was observed in KO mice. Hence, we conclude that the maternal hepatocyte ERα is involved in estradiol-induced hepatocyte proliferation in late pregnancy. |
| Databáze: | OpenAIRE |
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