Soluble FMS-Like Tyrosine Kinase-1: Role in placenta accreta spectrum disorder
| Autor: | Bancin Berry Eka Parda, Sarma N Lumbanraja, Andre Marolop Pangihutan Siahaan, M Rizki Yaznil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Placenta accreta Placenta viruses Placenta Accreta General Biochemistry Genetics and Molecular Biology Pregnancy Post-hoc analysis Humans Medicine General Pharmacology Toxicology and Pharmaceutics Gynecology Vascular Endothelial Growth Factor Receptor-1 General Immunology and Microbiology Cesarean Section business.industry Incidence (epidemiology) Uterus virus diseases General Medicine biochemical phenomena metabolism and nutrition medicine.disease digestive system diseases Pathophysiology medicine.anatomical_structure embryonic structures Mann–Whitney U test Female business Soluble fms-like tyrosine kinase-1 |
| Zdroj: | F1000Research. 10:618 |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.54719.2 |
| Popis: | Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sfltsFlt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Mann-Whitney U test, and Kruskal-Wallis analysis test, with a P-value Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. -Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study. |
| Databáze: | OpenAIRE |
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