Use of Bis-(chiral α-methylbenzyl)glycine Esters for Synthesis of Enantiopure β-Hydroxyamino Esters
| Autor: | Ayako Yamashita, R. Thomas Williamson, Douglas M. Ho, Sandra Sinishtaj, Tarek S. Mansour, Emily B. Norton |
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| Rok vydání: | 2003 |
| Předmět: |
Stereochemistry
education Glycine Peptidoglycan Crystallography X-Ray Hydroxamic Acids Biochemistry Aldol reaction polycyclic compounds Urea Organic chemistry Physical and Theoretical Chemistry Beta (finance) Aldehydes Molecular Structure Nucleotides Chemistry organic chemicals Organic Chemistry Esters Stereoisomerism General Medicine Anti-Bacterial Agents Enantiopure drug Peptides |
| Zdroj: | ChemInform. 34 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200350043 |
| Popis: | [reaction: see text] Aldol reactions using bis-(chiral alpha-methylbenzyl)glycine esters with aldehydes gave excellent diastereoselectivity. Thus, an enantiopure ribosylglycine was prepared for the synthesis of analogues of the natural antibiotics muraymycin. This method was extended for formation of beta-hydroxyamino esters. |
| Databáze: | OpenAIRE |
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