Combined magnetic porous molecularly imprinted polymers and deep eutectic solvents for efficient and selective extraction of aristolochic acid I and II from rat urine
| Autor: | Rui-Lin Liu, Xinya Xu, Chun Chang, Zhimin Luo, Pengqi Guo, Hua Shu, Yanhui Ge, Qiang Fu |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Choline Molecular Imprinting Biomaterials Glycols Magnetics chemistry.chemical_compound Column chromatography Adsorption Animals Chromatography High Pressure Liquid chemistry.chemical_classification Chromatography Solid Phase Extraction Extraction (chemistry) Molecularly imprinted polymer Polymer 021001 nanoscience & nanotechnology Rats 0104 chemical sciences Deep eutectic solvent chemistry Mechanics of Materials Solvents Aristolochic Acids Spectrophotometry Ultraviolet 0210 nano-technology Mesoporous material Porosity Choline chloride |
| Zdroj: | Materials Science and Engineering: C. 97:650-657 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2018.12.057 |
| Popis: | Aristolochia and related plants contain nephrotoxins and mutagens in the form of aristolochic acids (AAs). However, there is still lack of a fast and specific method for monitoring AAs in biological samples. Herein, we synthesized a hybrid magnetic mesoporous carbon-molecularly imprinted polymers (MMC@MIPs) as a novel magnetic solid-phase extraction (MSPE) adsorbent for selective recognition of aristolochic acid I and II from rat urine samples. The choline chloride/glycol-based deep eutectic solvent (DES) and indomethacin were used as the eluent and dummy template molecule accordingly. The morphology, structure property and surface groups of the prepared materials were investigated in sequence, and the optimum conditions of the MMC@MIPs-MSPE procedure were also optimized well. Results showed that the proposed method had a relatively satisfactory recovery (86.7-94.3%), with low standard deviation ( |
| Databáze: | OpenAIRE |
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