Left Ventricular-Based Cardiac Stimulation Post AV Nodal Ablation Evaluation (The PAVE Study)

Autor:	Luis A. Pires, Rahul N. Doshi, Mohamed H. Hamdan, Kyong Turk, Emile G. Daoud, Aurelio Duran, Christopher Fellows
Rok vydání:	2005
Předmět:	Male medicine.medical_specialty Heart Ventricles medicine.medical_treatment Management of atrial fibrillation Statistics Nonparametric Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Prospective Studies cardiovascular diseases Prospective cohort study Aged Analysis of Variance Chi-Square Distribution Ejection fraction business.industry Cardiac Pacing Artificial Stroke Volume Atrial fibrillation Stroke volume Middle Aged Ablation medicine.disease Combined Modality Therapy Atrioventricular node Treatment Outcome medicine.anatomical_structure Heart failure Atrioventricular Node Catheter Ablation Quality of Life cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business
Zdroj:	Journal of Cardiovascular Electrophysiology. 16:1160-1165
ISSN:	1540-8167 1045-3873
DOI:	10.1111/j.1540-8167.2005.50062.x
Popis:	BACKGROUND Chronic right ventricular pacing has been reported to promote cardiac dyssynchrony. The PAVE trial prospectively compared chronic biventricular pacing to right ventricular pacing in patients undergoing ablation of the AV node for management of atrial fibrillation with rapid ventricular rates. METHODS AND RESULTS One hundred and eighty-four patients requiring AV node ablation were randomized to receive a biventricular pacing system (n = 103) or a right ventricular pacing system (n = 81). The study endpoints were change in the 6-minute hallway walk test, quality of life, and left ventricular ejection fraction. Patient characteristics were similar (64% male; age: 69 +/- 10 years, ejection fraction: 0.46 +/- 0.16; 83%, NYHA Class II or III). At 6 months postablation, patients treated with cardiac resynchronization had a significant improvement in 6-minute walk distance, (31%) above baseline (82.9 +/- 94.7 m), compared to patients receiving right ventricular pacing, (24%) above baseline (61.2 +/- 90.0 m) (P = 0.04). There were no significant differences in the quality-of-life parameters. At 6 months postablation, the ejection fraction in the biventricular group (0.46 +/- 0.13) was significantly greater in comparison to patients receiving right ventricular pacing (0.41 +/- 0.13, P = 0.03). Patients with an ejection fraction
Databáze:	OpenAIRE
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