The Pipeline Embolization Device: a decade of lessons learned in the treatment of posterior circulation aneurysms in a multicenter cohort

Autor: Adam A, Dmytriw, Mahmoud, Dibas, Nimer, Adeeb, Mohamed M, Salem, Arsalaan, Salehani, Muhammad, Waqas, Amro, Saad Aldine, Vincent M, Tutino, Christopher S, Ogilvy, Adnan H, Siddiqui, Mark R, Harrigan, Ajith J, Thomas, Hugo, Cuellar, Christoph J, Griessenauer
Rok vydání: 2022
Předmět:
Zdroj: Journal of Neurosurgery. 137:1454-1461
ISSN: 1933-0693
0022-3085
DOI: 10.3171/2021.12.jns212201
Popis: OBJECTIVE The Pipeline Embolization Device (PED) has prompted a paradigm shift in the approach to posterior circulation aneurysms. The year 2021 marks a decade since FDA approval of this flow diverter, and during this time operators have adapted to its off-label uses. The authors examined whether case selection, practice trends, and patient outcomes have changed over this 10-year period. METHODS This study is a retrospective review of consecutive posterior circulation aneurysms managed with the PED at four academic institutions in the US between January 1, 2011, and January 1, 2021. Factors related to case selection, rates of aneurysm occlusion, or complications were identified and evaluated. Angiographic outcomes as well as thromboembolic and hemorrhagic complications were investigated. RESULTS This study included 117 patients (median age 60 years). At a median follow-up of 12 months, adequate occlusion (> 90%) was attained in 73.2% of aneurysms. Aneurysm occlusion rates were similar over the study interval. Thromboembolic and hemorrhagic complications were reported in 12.0% and 6.0% of the procedures, respectively. There was a nonsignificant trend toward a decline in the rate of thromboembolic (14.1% in 2011–2015 vs 9.4% in 2016–2021, p = 0.443) and hemorrhagic (9.4% in 2011–2015 vs 1.9% in 2016–2021, p = 0.089) complications. CONCLUSIONS The authors observed a trend toward a decline in the rate of thromboembolic and hemorrhagic complications with improved operator experience in using the PED for posterior circulation aneurysms. The use of single-device PED flow diversion significantly increased, as did the tendency to treat smaller aneurysms and observe large unruptured fusiform/dolichoectatic lesions. These findings reflect changes attributable to evolving judgment with maturing experience in PED use.
Databáze: OpenAIRE
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