Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study

Autor: Kazuhiko Tsuruya, Yui Arita, Masaru Nakayama, Makiko Seki, Kimika Arakawa, Mitsuhiro Tominaga, Toshiaki Nakano, Yuta Matsukuma, Yuri Sonoda, Takanari Kitazono, Rina Imazu, Akiko Fukui, Susumu Tsuda, Ryota Yoshitomi
Rok vydání: 2019
Předmět:
Nephrology
Carotid Artery Diseases
Male
medicine.medical_treatment
lcsh:RC870-923
Chronic kidney disease
Vitamin D
Carotid artery plaque
Aged
80 and over
education.field_of_study
Calcinosis
Phosphorus
Middle Aged
Echocardiography
Parathyroid Hormone
Aortic Valve
Aortic valve calcification
Cardiology
Female
Research Article
Adult
medicine.medical_specialty
Population
Renal function
Peripheral Arterial Disease
Young Adult
Internal medicine
medicine
Humans
Ankle Brachial Index
Lansoprazole
Renal Insufficiency
Chronic
education
Dialysis
Aged
Peripheral artery disease
business.industry
Odds ratio
Aortic Valve Stenosis
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Atherosclerosis
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Blood pressure
Cross-Sectional Studies
Calcium
business
Kidney disease
Zdroj: BMC Nephrology
BMC Nephrology, Vol 21, Iss 1, Pp 1-8 (2020)
ISSN: 1471-2369
Popis: Background Patients with chronic kidney disease (CKD) reportedly have a high prevalence of aortic valve calcification (AVC). In population-based studies, AVC is considered a manifestation of systemic atherosclerosis. The association of AVC with atherosclerotic lesions has not been fully investigated in predialysis patients. The present study was performed to determine whether carotid artery lesions and peripheral artery disease (PAD) are associated with AVC in patients with CKD not on dialysis. Methods In total, 749 patients were included in this cross-sectional study. AVC was evaluated using echocardiography. Carotid artery lesions including carotid artery plaque (CAP) and PAD were simultaneously examined in each patient. A logistic regression analysis was applied to determine the factors associated with AVC. Results AVC, CAP, and PAD were found in 201, 583, and 123 patients, respectively. In the multivariable analyses adjusted for covariates including the estimated glomerular filtration rate and makers of mineral metabolism (serum calcium, serum phosphorus, parathyroid hormone, 1,25-dihydroxyvitamin D, and fibroblast growth factor 23), AVC was significantly associated with the presence of CAP [odds ratio (OR), 3.37; 95% confidence interval (CI), 1.43–7.95], the presence of PAD (OR, 1.76; 95% CI, 1.10–2.81), the CAP score (per 1.0-point increase) (OR, 1.06; 95% CI, 1.02–1.11), and the ankle-brachial blood pressure index (per 0.1-point increase) (OR, 0.83; 95% CI, 0.72–0.95). Conclusions AVC was associated with atherosclerotic lesions independent of kidney function and mineral metabolism. We consider that this association between AVC and atherosclerosis might reflect the burden of shared atherosclerotic risk factors.
Databáze: OpenAIRE
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