Risk stratification of the patients with Brugada type electrocardiogram: a community-based prospective study
| Autor: | Stefano Drago, Carla Giustetto, Roberta Bertona, Francesca Bianchi, Paola Dalmasso, Cardiostimulation (AIAC)-Piedmont Section, Pier Giuseppe Demarchi, Eraldo Occhetta, Andrea Sibona Masi, Riccardo Riccardi, Fiorenzo Gaita, Guido Rossetti, Paula Carvalho |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Kaplan-Meier Estimate Asymptomatic Sudden death Severity of Illness Index Syncope Electrocardiography Young Adult Risk Factors Physiology (medical) Internal medicine Severity of illness Genetics medicine Humans cardiovascular diseases Prospective Studies education Prospective cohort study Child Aged Brugada Syndrome education.field_of_study medicine.diagnostic_test business.industry Arrhythmia Electrophysiology Incidence (epidemiology) Arrhythmias Cardiac Middle Aged medicine.disease Defibrillators Implantable Death Sudden Cardiac Treatment Outcome Italy Ventricular fibrillation Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 11(4) |
| ISSN: | 1532-2092 |
| Popis: | Aims Risk stratification of patients with Brugada electrocardiogram (ECG) is being strongly debated. Conflicting results have been suggested from international registries, which enrolled non-consecutive cases, studied with different programmed electrical stimulation (PES) protocols. The aim of this study was to prospectively evaluate the incidence of arrhythmic events and the prognostic role of clinical presentation, ECG, and of a standardized PES protocol in consecutive cases from a community-based population. Methods and results A total of 166 consecutive patients (45 ± 14 years) with Brugada ECG were enrolled. Type 1 ECG was observed spontaneously in 72 (43%) and after pharmacological testing in 94 (57%). One hundred and three (62%) were asymptomatic, 58 (35%) had syncope, and five (3%) had a prior cardiac arrest. One hundred and thirty-five (81%) underwent PES with two extra stimuli up to ventricular refractoriness and 34% had ventricular fibrillation (VF) induced. Arrhythmic events occurred in nine patients at a mean follow-up of 30 ± 21 months (2.2 events per 100 person-year): in three (60%) patients with aborted sudden death (aSD), five (8.6%) of those with syncope, and one (1%) of the asymptomatic. The only predictors of events were a history of syncope or aSD ( P = 0.02) and induction at PES ( P = 0.004). Conclusion Clinical presentation is the most important parameter in the risk stratification of patients with Brugada ECG. Programmed electrical stimulation seems valuable, particularly in patients with previous syncope. |
| Databáze: | OpenAIRE |
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