Study of High-Resolution H1 Nuclear Magnetic Resonance Spectra of the Serum and Its Albumin Fraction in Patients with the First Schizophrenia Episode
| Autor: | Alexander S. Peregudov, G. E. Dobretsov, Yu. A. Gryzunov, M. G. Uzbekov, T. A. Babushkina, N. Smolina, T. P. Klimova |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Very low-density lipoprotein Adolescent Protein Conformation Serum albumin High resolution Lipoproteins VLDL General Biochemistry Genetics and Molecular Biology Nuclear magnetic resonance medicine Humans In patient Nuclear Magnetic Resonance Biomolecular Serum Albumin biology Chemistry Albumin Lipid metabolism General Medicine Lipid Metabolism Ligand (biochemistry) medicine.disease Lipoproteins LDL Schizophrenia biology.protein Female lipids (amino acids peptides and proteins) Protons |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:748-751 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-012-1622-y |
| Popis: | We studied high-resolution (1)H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the first episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH(2) protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH(2) and CH(3) protons of non-esterified fatty acids were found in (1)H nuclear magnetic resonance spectra of serum albumin. These data attest to an essential role of changes in lipid metabolism and changed ligand load of albumin in schizophrenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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